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Misialek JR, Lopez FL, Lutsey PL, Huxley RR, Peacock JM, Chen LY, Soliman EZ, Agarwal SK, Alonso A

thus we selected this model in our experiments

Larginine est un acide amin semi-essentiel, son apport exogne entrane une augmentation de L-Arginine plasmatique et des produits de son mtabolisme comme loxyde nitrique (NO), L-Glutamine et la cratine

Discussion With our approach combining epidemiological studies, explorative cellular experiments and murine interventions, we demonstrate that kidney function is the main modifiable factor consistently regulating fasting serum TMAO concentrations and that TMAO adversely impacts on eGFR, at least partially, by increasing kidney scarring synergistically with existing pathophysiology elevating kidney tissue TGF-1 signaling