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Discussion We review relevant literature suggesting in utero inflammation can lead to preterm labor, while insufficient development of the gut-bloodbrain barriers could permit exposure to potential neurotoxins

Dyslipidemia, hyperglycemia, along with other metabolic disorders, results in IR and/or islet cell dysfunction via some shared pathways, such as inflammation, endoplasmic reticulum stress (ERS), oxidative stress, and ectopic lipid deposition

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