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Acknowledgements This work was supported by grants NIH R35HL135828 (Y.-J.H.), NIH R01HL137268, R01HL085646, R01HL138708, R21AG055325 (Av.dV.), NIH R01HL122383 and R01HL141364, RO1HL136917 (V.A.)

Vitamin C reconfigures the gut microbiota, improves the intestinal environment, reduces inflammatory responses and oxidative stress in the paraventricular nucleus of the hypothalamus, thereby weakening sympathetic nervous activity in hypertensive rats and lowering blood pressure (83)