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The mRNA and protein expression of the GSH biosynthesis pathway (GCLC, GCLM, GSS, and GSR) were downregulated in GCLC knockdown cells (Fig

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During cellular transport, glutamate and cystine are exchanged between cells through system Xc, which is key for GSH synthesis (26)

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Hence, as part of the defense against the ROS, organisms developed an intricate network of antioxidants that inhibits the oxidation of other molecules by terminating the reactions leading to the production of free radicals