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63: 492498 [DOI] [PubMed] [Google Scholar] 168.Zander M, Madsbad S, Madsen JL, et al

A 2024 review published in Diabetes, Obesity & Metabolism (cited by Endocrine News, September 2025) put the range at 15% to 60% of total weight lost potentially coming from lean mass - with the spread reflecting real differences in patient age, which drug, and what the person is doing (or not doing) with their nutrition and training

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I think we will hear more about muscle loss over time - while less than fat loss, it is certainly an issue with GLP-1 RAs, and I suspect will become more of an issue in those not exercising sufficiently (so probably less of an issue in the body building community!)