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Further research has shown that liver proliferation and cancer progression are driven by the downregulation of SIRT1 and its downstream effector, PGC-1, which is suppressed by the CCAAT/enhancer binding protein -histone deacetylase 1 complex (Jin et al., 2013)

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Cruciferous vegetables are preferred due to their high content of indole-3-carbonyl and sulforaphane, which powerfully enhance estrogen metabolism and detoxification (20)

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