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The most frequently used oxirane for this purpose is 1,4-butanediol diglycidyl ether, which contains two epoxy groups
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Moreover, administration of Vit-C (1 mM) resembled TET2 recovery, by increasing 5hmC production in Tet2-deficient mice primary murine hematopoietic stem and progenitor cells (HSPCs), as well as suppressing human leukemic colony production and leukemia development in human primary leukemia [185]
Measurable concentrations exist in human blood plasma, and those concentrations respond to physiological states
He et al., 2018
