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An increased activity of estrogen receptors (ERs), a local estrogen production in endometriotic cells, and a progesterone receptor decreased activity (progesterone-resistance) are considered the main causes of impaired apoptosis, reduced immune function, and increased inflammation [18]
10.1111/j.1432-1033.1987.tb11155.x Eur J Biochem
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In addition, rare cases of severe hepatic reactions, including jaundice and fatal fulminant hepatitis, liver necrosis and hepatic failure, some of them with fatal outcomes have been reported

Maybe you've noticed it on your blood work, or perhaps you've heard other guys in TRT forums talking about it

Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system