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It activates genes involved in DNA repair, stress response, matrix remodeling and antioxidant defense, while suppressing genes associated with inflammation, fibrosis and tissue destruction
retatrutide produced 24% at 12 mg over 48 weeks in Phase 2 and 29% over 68 weeks in a Phase 3 osteoarthritis trial
10.1038/s41579-018-0121-1 Nat
Cortex 74:358369, 2016
BJOB An International Journal of Obstetrics and Gynaecology 7
