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Completely removing eosinophils (as done in some trials with IL-5 antibodies) surprisingly doesn't cause major immunodeficiency in adults, but subtle effects exist (e.g., delayed clearance of some viruses, possible impact on tissue remodeling) (242)

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Br J Pharmacol 119(8):15331540 Mehta R, Pascual M, Soroko S, Savage B, Himmelfarb J, Ikizler T, Paganini E, Chertow G (2004) Spectrum of acute renal failure in the intensive care unit: the PICARD experience