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resistant to biotype GP) and Newton (susceptible to biotype GP) were planted in groups of 20 seeds per pot (4-inch in diameter) containing Promix Professional growing medium (Premier Horticulture Inc., Quakertown, PA)

The variability of the C-terminal domain of GSTs enables these enzymes to use a variety of substrates to bind activated glutathione to most hydrophobic compounds containing electrophilic atoms [4]

However, evidence shows that spontaneous or enzyme mediated DA oxidation can trigger specific oxidative stress in dopaminergic neurons 21 producing ROS, DA quinones (DAQs) and 3,4-dihydroxyphenylacetaldehyde (DOPAL) 16

The haem in CBS plays a key role in switching the transsulfuration pathway from cysteine production to H 2 S generation (Kabil et al ., 2016)

This cofactor insufficiency phenotype suggests that even intact flavoproteins may lose activity when the flavin supply is compromised, expanding the scope of riboflavin-responding conditions

J Biochem 145:701708 Li Y, Wei G, Chen J (2004) Glutathione: a review on biotechnological production