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Also, the covalent attachment of different polymers can elevate the molecular weight and hydrodynamic volume of the peptide, thus lowering renal clearance
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4 We then discuss the trafficking of metals to downstream metalloenzyme targets, contextualizing this discussion around the concept of a metallochaperone, focusing first on the biogenesis or maturation of metallocofactors in specific enzymes, followed by moving metals across a membrane
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