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The different nature of these residues is suggested to be responsible for the differences in catalytic properties of mesophilic and extremophilic GGTs ( FIGURE 5 Recent crystallographic studies on L-Glu-bound BlGGT demonstrated that its active site channel constitutes two extensive pockets at the intersubunit interface lined mainly by hydrophobic residues

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Activation of TLR3 receptors in microglia causes increased release of IL-1 and TNF-, which increases SERT expression in astrocytes and, therefore, 5-HT reuptake and its degradation to the metabolite 5-HIAA, thus reducing extracellular 5-HT levels

Reconstituted: 28 C, use within 14 days