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Reactive oxygen species (ROS) generated by oxidative stress can directly compromise the bloodbrain barrier (BBB) integrity and recruit peripheral immune cells, initiating inflammatory cascades that exacerbate ischemic and surrounding brain tissue (1719)

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People with bleeding disorders or taking blood thinning medications should avoid taking NAC because it may slow the blood clotting process

Imechanistic assays on ROS, glutathione depletion and calcein uptake

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