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Heart disease is the leading cause of death in senior dogs, affecting 1 in 10 dogs overall and up to 75% of senior dogs

The accumulation and misfolding of -syn is due in part to post-translation modification, particularly phosphorylation and nitration that can be exacerbated by oxidative stress (Brembati et al., 2023)

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Oxidation: Product may gradually oxidize over time when exposed to air, heat, or humidity

Front Physiol 11(11):103 Cimen B, Uz A, Cetin I, Cimen L, Cetin A (2017) Melatonin supplementation ameliorates energy charge and oxidative stress induced by acute exercise in rat heart tissue

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