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Research Priorities Priority studies should include rigorous human PK (multiple routes, dose proportionality), double blind placebo controlled dose ranging Phase II trials for a single indication (e.g

Layered defense: how mucus and tight junctions seal the intestinal barrier

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Mechanism of regulation of intestinal epithelial tight junction proteins A crucial function of IECs is the maintenance of barrier integrity, which allows the permeability of essential ions, nutrients, and water but restricts the entry of bacterial toxins and pathogens 21