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You may need to take a period of time between stopping one medication and starting another to make sure the medications do not overlap and reduce side effects during the adjustment period

CrossRef Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice Kana N

Enhanced endosomal signaling and desensitization of GLP-1R vs GIPR in pancreatic cells

Hawthorne G, Robson S, Ryall EA, Sen D, Roberts SH, Ward Platt MP

Dosing started low and escalated gradually every four weeks, following the 'start low, go slow' protocol that reduces gastrointestinal side effects during the adjustment period