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Sato et al., 2013
Nutriton and Cancer 62: 11371141

ChIP assay and luciferase reporter assay further revealed that SOX2 directly upregulated Dickkopf WNT Signalling Pathway Inhibitor 1 (DKK1), thus antagonizing the WNT signalling pathway, which is a critical switch in enhancing osteogenesis and inhibiting adipogenesis [29]

Despite the fact that only 2% of ADCs successfully reach tumor targets after intravenous administration [52], these highly cytotoxic agents retain substantial efficacy even at low concentrations, highlighting their potency

Developed by Theratechnologies Inc., it underwent phase II trials in the mid-2000s for GH deficiency (GHD) and HIV lipodystrophy but was discontinued, with reported reasons including hypersensitivity reactions, including an anaphylaxis-like reaction in one trial participant Wong et al (2008) [Note: Abstract only

Ultimately, McGuire says, these researchers concluded that the protective agent was a peptide naturally found in gastric juice
