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A 2022 editorial review by Sikiric and colleagues in World Journal of Gastroenterology synthesized prior rat work on major vessel occlusion, Pringle-maneuver ischemia-reperfusion, and Budd-Chiari syndrome, framing collateral-vessel recruitment as a proposed mechanism by which BPC-157 may compensate for occluded flow a narrative synthesis that does not itself report original effect sizes or p-values

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Answer: BPC-157 and TB-500 are both synthetic (laboratory-made) peptides that have been promoted for many uses based mainly on findings in animal studies: BPC-157 for improving bone and joint health, stomach ulcers, bladder pain, athletic performance enhancement, and anti-aging effects, and TB-500 for wound healing, injury recovery, strength and endurance

Amyotrophic lateral sclerosis associated FUS mutation shortens mitochondria and induces neurotoxicity

Adapted from Burns and Kidron (2022), Hartman (2024), and Holden (2000)

Therefore, since the early 1990s, we have presented stable gastric pentadecapeptide BPC 157, and its pleiotropic beneficial effects, acting also via the per oral route [3,4,5,6,7,8,9,10,11,12,13,14,16,17,18,19,20,21,22,23,24,27,28,29,30,31,32,34,37,39,40], as a late advantage of Robert and Szabos concept of cytoprotection [41,42,43,44,45,46,47,48,49]