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doi: 10.1128/AEM.00324-14 84 JostinsL.RipkeS.WeersmaR

13 C NMR (126 MHz, CDCl 3 ) 168.71 (C 2), 134.99 (d, J = 3.0 Hz, CH 6), 133.91 (d, J = 10.0 Hz, CH 12), 130.54 (d, J = 12.6 Hz, CH 12), 118.46 (d, J = 85.8 Hz, C 6), 41.18 (CH 2 2), 38.81 (CH 2 2), 27.96 (CH 2 2), 27.45 (d, J = 17.3 Hz, CH 2 2), 22.66 (d, J = 50.3 Hz, CH 2 2), 22.13 (d, J = 4.4 Hz, CH 2 2)

Due to its strong bond with heme iron, CO inhibits the transport of oxygen in the blood, while interacting with cytochrome c oxygenase and cytochrome p450 it inhibits cellular respiration and promotes tissue death (66)

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Metallothioneins have been reported to play a role in modulating ERK phosphorylation and regulating ROS levels through heme oxygenase-1 (HO-1) (Qu and Waalkes, 2013[351])

Pharmacognosy:233266 Kamran S, Sinniah A, Abdulghani MAM, Alshawsh MA (2022) Therapeutic potential of certain terpenoids as anticancer agents: a scoping review
