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Some research suggests visceral fat reduction may occur earlier than subcutaneous fat loss, which may explain why metabolic improvements sometimes precede visible changes

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A surprising number of medications can deplete the body of vitamin B12

Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency