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An ex vivo study of FA uptake and metabolism was also conducted in isolated cerebral vessels from APOE-TR mice

Acetate is further metabolized to acetyl-CoA by acetyl CoA synthetase (Acs) enzymes and transported into mitochondria by a carnitine dependent mechanism

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Follow up and outcome endpoints The clinical follow-up was performed by clinical visits and/or structured phone interviews at 36 months and each year after enrollment 33 .The primary outcome was a combination of major adverse events (AEs), including all-cause death and non-fatal myocardial infarction

The side effects aren't the limiting factor