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Patients should attend scheduled follow-up appointments and report persistent fatigue, as this may indicate the need for nutritional assessment, blood tests (including full blood count, thyroid function, vitamin B12, vitamin D, and potentially renal function/electrolytes), or medication adjustment

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2 To mitigate side effects, these medications are started at a low dose and increased over time

1995;18(Suppl 1):S59S64

Studies report that PD-1 engagement downregulates PGC-1, a master regulator of mitochondrial biogenesis, impairing mitochondrial integrity and long-term persistence