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Intracellular cystine depletion by aminothiols in vitro and in vivo

The Secretary's regulations permit hospitals, through a Medicare GME affiliation agreement, to increase or decrease their IME and direct GME FTE resident caps to reflect the rotation of residents among affiliated hospitals for agreed-upon academic years

Consequently, left ventricular end-diastolic pressure rises precipitously, causing a dramatic fall in forward stroke volume that manifests as profound hypotension, weak pulses, pallor, and reflex tachycardia