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Meanwhile, long-term use also disrupts intestinal microbiota (bacteria and fungi), risks multidrug-resistant fungi, and carries hepatotoxic or even fatal side effects 169,170

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Brown R.E., Basheer R., McKenna J.T., Strecker R.E., McCarley R.W
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Therapeutic antisense oligonucleotides are coming of age
1 To further explain aging from the perspective of harmful inflammation and weakened immunity, inflammaging was introduced as an evolutionary perspective on immunosenescence, referring to the phenomenon of low-grade, chronic damage resulting from increased inflammation levels within the body

elegans , the effect was abolished by supplementing antioxidants [106]
