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Among these, severe alcohol-associated hepatitis (sAH) is the most life-threatening, with 28-day and 90-day mortality rates of 20% and 30%, respectively [11, 12]

Suppressive effect of recombinant human thioredoxin on ultraviolet lightinduced inflammation and apoptosis in murine skin

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By targeting key metabolic pathwaysincluding glycolysis, lipid synthesis, glutamine utilization, and nucleotide metabolismflavonoids disrupt both the energy supply and biosynthetic demands essential for tumor survival and progression [129]

(c) in vivo models

Short-course studies report no overt toxicity at commonly used doses, but programs should include organ-system panels, cardiovascular telemetry where relevant, and pathology review for chronic exposures