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Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N -methyl( R )salsolinol

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In addition, studies have explored its association with molecular signals linked to tissue remodeling, suggesting a supportive role in recovery mechanisms (16)

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Early-Stage Exploratory Drugs: In the very early stages of drug discovery, for exploratory compounds with limited information, basic SP studies might be sufficient