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10.1016/j.chemosphere.2018.03.196 48 KimJ

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For protocols extending beyond 8 weeks, monthly tracking of key parameters may be appropriate

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Improved Insulin Sensitivity Both agents help regulate blood sugar, promoting better glycemic control

Emerging data implicates gut dysbiosisa disruption in microbial composition and functionin the pathogenesis of diverse diseases, including reproductive and gynecological disorders ( A meta-analysis revealed that the most prevalent bacterial alterations in PCOS, including Bacteroidaceae , Coprococcus , Bacteroides , Prevotella , Lactobacillus , Parabacteroides , Escherichia/Shigella , and Faecalibacterium prausnitzii ( Lachnospira and Prevotella , alongside an enrichment of Bacteroides , Parabacteroides , Lactobacillus , Fusobacterium and Escherichia/Shigella in women with PCOS ( Bacteroides sharing 99.2% sequence similarity with Bacteroides acidifaciens , a species inversely correlated with obesitywas markedly diminished in PCOS-like mouse models ( Bacteroidetes and Actinobacteria while reducing Firmicutes at the phylum level ( Bifidobacteriaceae and suppresses Streptococcus at the family level ( Lactobacillus and inhibits Enterobacter ( Gpat1 (glycerol-3-phosphate acyltransferase 1), Mogat (monoacylglycerol O-acyltransferase), and Pparg (PPAR-), through microbiota-dependent mechanisms