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The situation is distinct in many other tumor types, where CA IX is expressed regionally in areas that are hypoxic and/or acidic (as explained above) and usually increases with increasing tumor stage and grade

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[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Pena-Diaz S., Pujols J., Vasili E., Pinheiro F., Santos J., Manglano-Artunedo Z., Outeiro T.F., Ventura S

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