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Together, these systems synergistically safeguard cells against oxidative damage ( 3 The role of ROS in the formation of calcium oxalate renal stones It is now well-recognized that the injury to RTCs and subsequent formation of stones attributed to oxalate is due to the interaction of oxalate with the kidney generating ROS ( Studies conducted in vitro on cells, in vivo on animals, and clinical case studies have all shown that RTCs exposed to oxalate and/or calcium oxalate crystals generate excessive ROS, triggering oxidative stress and inflammatory reactions

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The maturation of the FeS cluster proteins in the cytosol is performed by a different machinery from that of the ISC system that depends on substrates that must be exported out of the mitochondrion

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doi: 10.1038/s41571-019-0297-y Summary Keywords cell metabolism, cancer therapy, optimization strategy, CAR (chimeric antigen receptor) T cells, immunity therapy Citation Li W, Pan X, Chen L, Cui H, Mo S, Pan Y, Shen Y, Shi M, Wu J, Luo F, Liu J and Li N (2023) Cell metabolism-based optimization strategy of CAR-T cell function in cancer therapy