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This may be explained by the fact that glutamatergic neurons constitute the vast majority of the neuronal population (Braitenberg and Schz 1998), hence general elevation of brain glutamine levels will not only support GABAergic neurons but even more so the dominant population of excitatory glutamatergic neurons (Figure 1)

Lancet Gastroenterol Hepatol 6, 903913

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However, when these cells differentiate, GSH decreases nearly four times and oxidative conditions increase (Zhou et al., 2016)

71 These modulators can potentially provide more selective activation of the receptor, reducing adverse effects and improving efficacy
MSC: mesenchymal stem cells
