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In esophageal injury models, BPC-157 normalizes sphincter function by increasing pressure in both the lower esophageal sphincter (LES) and pyloric sphincter (PS) in animals with sphincter dysfunction, while in healthy animals the peptide demonstrates adaptive effects that maintain physiological sphincter tone

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[DOI] [PubMed] [Google Scholar] 25.Yamano S., Takahashi A., Todaka T., Toki S