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Once in circulation, these toxins can migrate to the joints, triggering macrophage activation, synovial inflammation, and accelerated cartilage breakdown
doi: 10.1146/annurev-pharmtox-010818-021524 [DOI] [PubMed] [Google Scholar] 79.Bates D, Schultheis BC, Hanes MC, Jolly SM, Chakravarthy KV, Deer TR, et al
In addition, there is now emerging evidence that dysregulation of the intestinal barrier can affect distant organs such as the bone

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