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Whereas in normal conditions penile erection is mediated by the action of the two constitutive enzyme forms, neuronal (nNOS) and endothelial NOS (eNOS), which cause normal NO amounts to be produced, in pathological conditions and in PD high local nitric oxide radical (NO ) concentrations occur, due to mediation of the inducible enzyme form (iNOS) [34]

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strains is a good case-study to illustrate the feed-back between fundamental and applied research

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