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Antioxid Redox Signal 13: 16271637 Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S (2008) Cancer related mutations in NRF2 impair its recognition by Keap1Cul3 E3 ligase and promote malignancy

Bypasses FRA autoantibody blockade by using an alternate transport mechanism (Reduced Folate Carrier - RFC)

Its often used as a supplementary fat-burning aid

With their low risk profile, ease-of-use, and ability to activate deeper biological pathways, topical peptides are delivering real results without the harsh tradeoffs of traditional treatments

doi: 10.1126/science.1225416