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While alternative administration routes, such as intravenous, intramuscular, nasal, percutaneous, and transdermal delivery, have shown promise in certain conditions, these methods can be invasive and uncomfortable for patients

1 Introduction Hypothyroidism is a prevalent endocrine disorder defined by inadequate synthesis or secretion of thyroid hormones, primarily thyroxine (T 4) and triiodothyronine (T 3) (McDermott, 2020)

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