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therefore, we believe that a focus of future investigation on the interaction between Grx3 and different protein targets in vitro and in vivo , may lead to important discoveries about basic physiological mechanisms of life

Importantly, in active intestinal inflammation, HIF-2 may exert context-dependent effects on ferroptosis susceptibility: even under systemic iron deficiency, local inflammatory cues can paradoxically enhance epithelial iron uptake and/or perturb subcellular iron distribution, thereby increasing the labile iron pool and promoting lipid peroxidation

[DOI] [PubMed] [Google Scholar] Kiss G., Konrad C., Doczi J., Starkov A.A., Kawamata H., Manfredi G., Zhang S.F., Gibson G.E., Beal M.F., Adam-Vizi V., Chinopoulos C