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This linkage implies that the same may be true for NADPHthat diminished TCA cycle activity might stimulate NADPH production by 1C metabolismthough the enzymes in 1C metabolism that produce NADH and NADPH rely on the same folate derivatives, and it remains unclear whether the cell would prioritize reducing NAD+ over NADP+

Limitations The study has several limitations: (1) Our analysis relied on GWAS data primarily derived from European populations, so undetected population stratification or ancestry-related biases may have affected our results, and this also limits the generalizability of our findings to other ethnicities or populations worldwide

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