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For several additional loci, variants were either not present in the available summary statistics or did not reach statistical significance in the external datasets, although some demonstrated directionally consistent effects

Third, since conditional Slc7a11 knockout mice were unavailable, our in vivo analysis relied on pharmacologic inhibition of the cystine/glutamate transporter and cannot completely exclude off-target effects of sulfasalazine or the contribution of other cell types beyond dendritic cells and fibroblasts in glutathione synthesis

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Clin Cosmet Investig Dermatol 24:5157 Tagliaferri V, Romualdi D, Scarinci E, Cicco SD, Florio CD, Immediata V, Tropea A, Santarsiero CM et al (2018) Melatonin treatment may be able to restore menstrual cyclicity in women with PCOS: a pilot study