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Understanding how your body's metabolic profile and genetic predispositions in peptide signaling pathways may influence dosing sensitivity helps contextualize why provider-guided titration is essential

MRI was meticulously performed using a 15 T GE scanner equipped with an eight-channel, torso phased-array coil (Optima MR360

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10.1111/cns.12788 85 MoranM

Patients with at least a 1 point reduction in pain intensity at the end of a 3-week open-label titration phase were randomized to receive placebo or their optimal fixed dose over 12 weeks