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The aim of this narrative review is to integrate evidence from transcriptomics, GPCR signaling, GLP-1RA pharmacokinetics, -arrestin biology, and pharmacovigilance data to identify critical gaps and to propose a hypothesis-driven framework for semaglutide-associated oral and salivary dysfunction

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And in 2025, Wegovy also received FDA accelerated approval for the treatment of noncirrhotic metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver fibrosis, underscoring that these medications can impact disease processes well beyond body weight alone