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But more important than modifying risk factors, the GLP-1 RAs provide patients with type 2 diabetes on average a 14% relative risk reduction for major cardiovascular events, including: Cardiovascular death Heart attack Stroke Three GLP-1 RAs have been indicated by the FDA to reduce heart disease risk in people with type 2 diabetes who have or are at high risk for blockages of arteries of the heart, brain, and legs, also known as atherosclerotic cardiovascular disease (ASCVD): Dulaglutide, which is branded as Trulicity and is currently the only GLP-1 RA approved for cardiovascular disease risk reduction in patients with or without established ASCVD Liraglutide, which is branded as Victoza and was the first GLP-1 RA to show efficacy for heart benefits in a clinical trial Semaglutide, which has been increasingly prescribed off-label as a weight-loss medication under the brand name Ozempic Whereas we are still exploring the biological mechanisms of how GLP-1 Ras benefit the heart, the body of evidence we have at present is already revolutionizing the care of patients with type 2 diabetes

Patients should contact their GP if they experience rectal bleeding , even if they suspect it is due to haemorrhoids

This type of anemia be caused by a viral infection, the use of certain medications such as cancer drugs or antibiotics, and exposure to certain toxic substances

Real-world observational data from pharmacy and health system databases support these trial findings, showing low hypoglycemia incidence when semaglutide is prescribed without concurrent insulin or sulfonylureas

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The strategy underscores mounting pressure on large multinationals to balance scale with agility in response to inflation-worn shoppers and fragmented eating habits