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Hydroxyl radical is an extremely reactive oxidant, which are generated as a result of interaction of H 2 O 2 with transition metal ions such as Fe 2+ or Cu 2+ (Fenton reaction) and O 2 (Haber-Weiss reaction) as well as from peroxynitrite which is rapidly formed via the reaction between NO and O 2 Hydrogen peroxide is formed through dismutation of O 2 catalyzed by the enzyme superoxide dismutase, and is also produced by several other oxidase enzymes (e.g

Based on these findings, they advocate for clinical trials investigating the use of the epigenetic modulator RVX208 in PAH patients [114]