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Multiple pharmacological inhibitors, including S-p-bromobenzyl-glutathione cyclopentyl diester (BBGC), ethyl pyruvate, TER 117 and curcumin, have been shown to sensitize cancers to chemotherapy [121, 244, 245]

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This leads to the generation and expansion of immunosuppressive cell populations within the tumor microenvironment (TME), including myeloid-derived suppressor cells (MDSCs) and, critically, regulatory Treg cells ( TME Remodeling and Metastasis: HLA-G expression is not just a defensive shield

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.McEachin J.J., Smith T., Lovaas O.I