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Elife 7, e32111 10.7554/eLife.32111 [DOI] [PMC free article] [PubMed] [Google Scholar] 30.Jaiswal, N., Gavin, M.G., Quinn, III, W.J., Luongo, T.S., Gelfer, R.G., Baur, J.A.et al

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383 Moreover, we also found that bromodomain containing 4 (BRD4) is upregulated in ICB-resistant melanoma patients, and inhibiting BRD4/AKR1C2 axis by bromodomain and extra-terminal motif (BET) inhibitors has been shown to enhance the susceptibility of melanoma to ferroptosis and immunotherapy

Of all the substances, treatment with compounds 28 and 28d was the most successful in returning the biochemical mediators to their most normal state and significantly reduced the reactive oxygen and nitrogen species linked to the neuroinflammation mechanism (Table 1)

These natural products function as multi-target modulators of mitochondrial health