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9 Skin biopsies are rarely needed unless the diagnosis is in question

Murray (3rd time) (s.a.) 1991 - 199

Finally, as the hyperpigmentation coalesces, both follicular anatomical structures are infiltrated by malignant cells and the opening of follicle is obliterated

Earlier experimental studies have shown that reactive oxygen species (ROS) and plasminogen activator inhibitor 1 (PAI-1) induced by initial insults penile tissues are remarkably increased in fibrotic plaques and then result in oxidative stress (Vernet et al., 2002