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When NRF-2 is exposed to inflammation or oxidative stress (OS), it phosphorylates and translocates into the nucleus, giving rise to the transcription of proteins and antioxidant enzymes [7]

This phenomenon can be caused by the fact that the released elemental mercury can be re-oxidized in the intracellular compartment by several enzymes, such as catalase [120,121] and re-enter the catalytic GSH-depleting cycle, ultimately leading to a displacement of the intracellular redox potential towards less negative, pro-apoptotic or necrotic values

After equilibration, the trypsin digestion solution was added to the Tip and centrifuged at 2000 g for 5 min at 4 C

The diagnosis may be less convincing when the suspected drug has not been previously incriminated as causing liver damage

Enzymatic and immunological studies of uroporphyrinogen decarboxylase in familial porphyria cutanea tarda and hepatoerythropoietic porphyria

10.4049/jimmunol.0901363 17 BeatyO.3rdBergS.BlaneyS.MalogolowkinM.KrailoM.KnightR.et al (2010)