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Previous studies 39,40 have shown that the substrates of HA and PAGL/PAG formation compete with each other, and consequently result in decreased production of these compounds
R.BoehlesH.et al (2009)

Drug Discov Today 9: 10031011 Saijo K, Crotti A, Glass CK (2010) Nuclear receptors, inflammation, and neurodegenerative diseases

Exceeding anatomical capacity causes the solution to pool rather than diffuse, increasing pain and reducing bioavailability.

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