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The phrase usually refers to compounded or off-label dosing schedules that sit below 5 mg per week, sometimes at 2.5 mg or even 1 mg, marketed as a way to capture the appetite suppression and modest weight loss without the gastrointestinal side effects that hit hardest at higher doses

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Eligible studies were phase 2b-4 RCTs of at least 12 weeks comparing once-weekly semaglutide against injectable therapy in insulin-nave adults with T2DM

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