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The study of natural mutations has identified domains of the OCTN2 transporter important for substrate and co-substrate recognition and their transfer inside the cell

Under aerobic conditions, radical species are controlled by a quasi-equilibrium process (b), leading to the indirect generation of superoxide anion radicals

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The reference gene GADPH ID qRnoCIP0050838 (Biorad, USA) was used as an internal control to normalize the expression of target genes

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For example, in models of CRPC, upregulation of IGF-2 via the transcription factor GATA2 strongly contributed to chemotherapy resistance after docetaxel and cabazitaxel treatment, by activating numerous downstream kinases including IGF-1R and INSR